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Revolutionary research has shown that environmental factors such as diet can activate or deactivate certain genes. This can make us and our children more or less vulnerable to uncountable diseases.

Epigenetics is a new scientific field that has changed the way we think about genetics. We had always assumed that our genetic material was predetermined and beyond our influence. But researchers have challenged this assumption. They showed that lifestyle decisions can influence our genes by changing our epigenome, allowing us to adapt better to the environment. Interestingly, the changes in our epigenome are not permanent and can be changed by modifying our lifestyle.

What is most striking is that recent research has placed a large burden on all of us. Scientific studies on animal models have shown that epigenetic changes can be passed from the parent to the offspring. Although in humans this has not been studied as much due to ethical reasons, recent studies are pointing that epigenetic inheritance also occurs in us. Recent research suggested that diet during pregnancy critically influences the epigenetic inheritance of the embryo. Epigenetic studies have shown that pregnant women on unhealthy high calorific diets, increased the likelihood of their children developing obesity compared to those that ate a healthy diet. This shows that pregnant mothers are more responsible for their children’s future health than previously thought.

But not all of them actually develop obesity and many people have asked why. The reason is that individuals with epigenetic tags that say ‘obesity’ can make lifestyle decisions that may reverse the situation. For example, they might decide to eat healthily for the rest of their life causing their methyl markers to be removed.

What is fascinating about this, is that we can make positive changes to our health by inducing epigenetic changes. We may be doomed by our parents to have a greater risk of obesity but we can change our destiny by making good decisions. Eating healthily and having an active lifestyle will cause certain genes to be switched on while others will be turned off and reduce the risk of many diseases.

Epigenetics is also involved in cancer, where individual cells may have more methylation than normal. This will cause the inactivation of certain genes such as tumor suppressor genes, making it more likely for the cell to divide uncontrollably. The opposite can also be true; too little methylation may activate certain genes called oncogenes, that promote cell growth causing cancer.

epigenetic word graphicA study carried out by Zeng et al showed that a component in green tea called epigallocatechin-3-gallate has the ability to influence the epigenome, decreasing the risk of breast cancer. The compound was tested on a cell line of breast cancer cells to investigate its effect on the expression of various genes. One important observation was that this compound enhanced the expression of p53. This is a tumour suppressor gene that kills cells that divide uncontrollably, preventing tumor formation.

An epigenetic mechanism involving methylation was shown to be responsible for these observations. Zeng showed that epigallocatechin-3-gallate was able to inhibit an enzyme called DNA methyltransferase. This enzyme catalyses the addition of methyl groups to DNA. Due to inhibition of this enzyme, there was little methylation of the p53 gene so the gene was active, being able to control cell growth. This investigation suggests that drinking green tea on a daily basis may lower the risk of breast cancer by switching on genes that protect our cells via epigenetic mechanisms.

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