A double-blind randomized trial on 141 healthy volunteers aged 20 to 49 years old was performed in which one group received 10 grams of vitamin C intravenously while a placebo group received saline intravenously.
Fatigue scores, oxidative stress and plasma vitamin C and side effects were all measured. Fatigue levels, at two hours and one day post supplementation, were significantly reduced in the group receiving vitamin C, especially in those whose initial vitamin C levels were particularly low. No major side effects were reported in either group. (Nutrition Journal, January 2012)